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OBJECTIVES: Early diagnosis of insulin resistance (IR) is important to prevent the development of type 2 diabetes mellitus (DM). Type 2 DM is an endocrine disorder however some recent studies show that exocrine functions of the pa...
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OBJECTIVES: Early diagnosis of insulin resistance (IR) is important to prevent the development of type 2 diabetes mellitus (DM). Type 2 DM is an endocrine disorder however some recent studies show that exocrine functions of the pancreas are insufficient also. Our aim in this study to evaluate the relation of IR with pancreatic exocrine functions. MATERIALS and METHODS: Datas were taken from the laboratory information system in this retrospective study. Included subjects were separated to three groups according to the insulin sensitivity status determined by homeostatic model assessment. 335 subjects in insulin sensitive (IS), 275 in moderate IR, 164 in severe IR group. The median of the age is 45 (34-54). Serum lipase and amylase levels were used and compared between groups as an indicator of pancreatic exocrine functions. RESULTS: Serum amylase levels were 67.8, 63 and 65.3 U/L; serum lipase levels were 31, 31 and 25.5 U/L and serum lipase/amylase ratios were 47%, 50% and 38% in IS, moderate and severe IR respectively. There were significant differences in serum amylase between IS and moderate IR (p=0.02); in serum lipase between IS and severe IR, and also between moderate and severe IR (p<0.001); in serum lipase/amylase activity ratio between IS and moderate IR, IS and severe IR, and also moderate and severe IR (p= 0.015, p<0.001, p<0.001 respectively). CONCLUSIONS: Our results show that the exocrine functions of the pancreas are affected in insulin resistance and serum lipase/amylase activity ratio can be used as a new parameter to define and screen insulin sensitivity status of the body.
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This retrospective study was conducted to assess the serum lipase / amylase ratio in acute pancreatitis for South Indian population attending the clinics of Gastroenterology and Emergency medicine in the last five years. One thous...
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This retrospective study was conducted to assess the serum lipase / amylase ratio in acute pancreatitis for South Indian population attending the clinics of Gastroenterology and Emergency medicine in the last five years. One thousand one hundred and thirty two patients (768 males and 364 females) with acute pancreatitis (AP) were selected for the study. The diagnosis ofAP was based on clinical evaluation, Computed Tomography (CT) findings and biochemical parameters such as serum lipase and amylase. Based on the etiology, the groups were divided into alcoholic, biliary and miscellaneous AP. Based on CT findings, groups were divided into mild, moderate and severe AP. Serum lipase, amylase and lipase / amylase ratio were calculated and statistically analyzed. Serum lipase levels in alcoholic group (3226.3 +- 1384.7) were significantly lower in comparison to biliary (6064.5 +- 1640.8) group though the levels were not significantly different from miscellaneous group (2132.3 + 1210). Serum amylase values were significantly lower in alcoholic group (923.4 +- 557.5) in comparison to biliary (1736.2 +- 390.7) and there was significant difference between alcoholic and miscellaneous group (535.8 +- 477.6). The serum lipase / amylase ratio > 4 occurred in alcoholic group than with biliary and miscellaneous group. The sensitivity and specificity to predict alcoholic AP with lipase / amylase ratio at>4.0 was 84 % and59 % respectively. In conclusion the serum lipase to amylase ratio greater than 3.0 could be used to differentiate but keeping the cut off at 4.0 would be of higher sensitivity without much change in specificity. The serum lipase to amylase ratio with a cut off of 3.0 or greater is not useful to differentiate the severe AP from milder AP. Hence, serum amylase and lipase are important for evaluation of pancreatitis though it is not a gold standard for the diagnosis or assessment of severity of acute pancreatitis.
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摘要 :
This retrospective study was conducted to assess the serum lipase / amylase ratio in acute pancreatitis for South Indian population attending the clinics of Gastroenterology and Emergency medicine in the last five years. One thous...
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This retrospective study was conducted to assess the serum lipase / amylase ratio in acute pancreatitis for South Indian population attending the clinics of Gastroenterology and Emergency medicine in the last five years. One thousand one hundred and thirty two patients (768 males and 364 females) with acute pancreatitis (AP) were selected for the study. The diagnosis ofAP was based on clinical evaluation, Computed Tomography (CT) findings and biochemical parameters such as serum lipase and amylase. Based on the etiology, the groups were divided into alcoholic, biliary and miscellaneous AP. Based on CT findings, groups were divided into mild, moderate and severe AP. Serum lipase, amylase and lipase / amylase ratio were calculated and statistically analyzed. Serum lipase levels in alcoholic group (3226.3 +- 1384.7) were significantly lower in comparison to biliary (6064.5 +- 1640.8) group though the levels were not significantly different from miscellaneous group (2132.3 + 1210). Serum amylase values were significantly lower in alcoholic group (923.4 +- 557.5) in comparison to biliary (1736.2 +- 390.7) and there was significant difference between alcoholic and miscellaneous group (535.8 +- 477.6). The serum lipase / amylase ratio > 4 occurred in alcoholic group than with biliary and miscellaneous group. The sensitivity and specificity to predict alcoholic AP with lipase / amylase ratio at>4.0 was 84 % and59 % respectively. In conclusion the serum lipase to amylase ratio greater than 3.0 could be used to differentiate but keeping the cut off at 4.0 would be of higher sensitivity without much change in specificity. The serum lipase to amylase ratio with a cut off of 3.0 or greater is not useful to differentiate the severe AP from milder AP. Hence, serum amylase and lipase are important for evaluation of pancreatitis though it is not a gold standard for the diagnosis or assessment of severity of acute pancreatitis.
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摘要 :
This retrospective study was conducted to assess the serum lipase / amylase ratio in acute pancreatitis for South Indian population attending the clinics of Gastroenterology and Emergency medicine in the last five years. One thous...
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This retrospective study was conducted to assess the serum lipase / amylase ratio in acute pancreatitis for South Indian population attending the clinics of Gastroenterology and Emergency medicine in the last five years. One thousand one hundred and thirty two patients (768 males and 364 females) with acute pancreatitis (AP) were selected for the study. The diagnosis of AP was based on clinical evaluation, Computed Tomography (CT) findings and biochemical parameters such as serum lipase and amylase. Based on the etiology, the groups were divided into alcoholic, biliary and miscellaneous AP. Based on CT findings, groups were divided into mild, moderate and severe AP. Serum lipase, amylase and lipase / amylase ratio were calculated and statistically analyzed. Serum lipase levels in alcoholic group (3226.3 ± 1384.7) were significantly lower in comparison to biliary (6064.5 ± 1640.8) group though the levels were not significantly different from miscellaneous group (2132.3 ± 1210). Serum amylase values were significantly lower in alcoholic group (923.4 ± 557.5) in comparison to biliary (1736.2 ± 390.7) and there was significant difference between alcoholic and miscellaneous group (535.8 ± 477.6). The serum lipase / amylase ratio > 4 occurred in alcoholic group than with biliary and miscellaneous group. The sensitivity and specificity to predict alcoholic AP with lipase / amylase ratio at >4.0 was 84 % and 59 % respectively. In conclusion the serum lipase to amylase ratio greater than 3.0 could be used to differentiate but keeping the cut off at 4.0 would be of higher sensitivity without much change in specificity. The serum lipase to amylase ratio with a cut off of 3.0 or greater is not useful to differentiate the severe AP from milder AP. Hence, serum amylase and lipase are important for evaluation of pancreatitis though it is not a gold standard for the diagnosis or assessment of severity of acute pancreatitis.
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Two 8-week trials, one in spring and the other in autumn-winter, were performed with sea bass fingerlings. After each growth period, pancreatic digestive enzyme synthesis in the pyloric caeca (PC), food anticipatory activity adapt...
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Two 8-week trials, one in spring and the other in autumn-winter, were performed with sea bass fingerlings. After each growth period, pancreatic digestive enzyme synthesis in the pyloric caeca (PC), food anticipatory activity adaptation in the proximal intestine (PI) and nutrient absorption capacities in the distal intestine were measured at 24 h post-feeding.
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We compared the nutritional requirements of whole larvae of the black seabream Acanthopagrus schlegeli, sweet fish Plecoglossus altivelis, olive flounder Paralichthys olivaeus and rock fish Sebastes schlegeli. The larvae were 20, ...
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We compared the nutritional requirements of whole larvae of the black seabream Acanthopagrus schlegeli, sweet fish Plecoglossus altivelis, olive flounder Paralichthys olivaeus and rock fish Sebastes schlegeli. The larvae were 20, 30, 14 and 5 DAH (orspawning) of black seabream, sweet fish, olive flounder and rock fish, respectively. Specific a-amylase activity (mU/mg protein) was highest (8,324.9 mU/mg protein) in rock fish larvae (P<0.05). Specific trypsin-like protease activity was highest (11,330.1 mU/mg protein) in black seabream larvae (PO.05), which also exhibited the highest activity, 685.5 mU/mg dry weight (P<0.05). The specific activities per mg protein and mg dry weight of black seabream were the highest (187.4 mU/mg protein and 11.3 mU/mg dry weight, respectively) (P<0.05). A/P, P/L and A/L ratios of rock fish were 1.47, 90.3 and 133.1, respectively (P<0.05). We present here basic larval digestive enzymatic nutritional requirement data.
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